TOPBP1 and TCFL5

Data Source:
HPRD (in vivo)

		TOPBP1	TCFL5
Description		DNA topoisomerase II binding protein 1	transcription factor like 5
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle	Chromatin Male Germ Cell Nucleus Nucleus
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation
Pathways		HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Obesity-related traits ( 23251661)
Interacting Genes		32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17	2 interacting genes: TOPBP1 USF1
Entrez ID		11073	10732
HPRD ID		09678	05297
Ensembl ID		ENSG00000163781	ENSG00000101190
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q86TP4 Q9UL49
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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