HSPA9 and YKT6

Data Source:
BioGRID (two hybrid)

		HSPA9	YKT6
Description		heat shock protein family A (Hsp70) member 9	YKT6 v-SNARE homolog
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GO Annotations	Cellular Component	SAM Complex Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Focal Adhesion Mitochondrial Nucleoid Extracellular Exosome MIB Complex	Golgi Membrane Cytoplasm Mitochondrion Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Apical Dendrite Basal Dendrite
	Molecular Function	RNA Binding Protein Binding ATP Binding ATPase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding Misfolded Protein Binding	SNAP Receptor Activity Protein-cysteine S-palmitoyltransferase Activity Cadherin Binding
	Biological Process	Protein Export From Nucleus Inner Mitochondrial Membrane Organization Iron-sulfur Cluster Assembly Erythrocyte Differentiation Cellular Response To Unfolded Protein Interleukin-12-mediated Signaling Pathway Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Hemopoiesis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Targeting Vesicle Docking Involved In Exocytosis Protein Transport Protein Phosphopantetheinylation Retrograde Transport, Endosome To Golgi Membrane Fusion
Pathways		Mitochondrial protein import Regulation of HSF1-mediated heat shock response Cristae formation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	COPII-mediated vesicle transport COPI-mediated anterograde transport Intra-Golgi traffic
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061 29483656)	Birth weight ( 31043758 27680694) Blood sugar levels ( 29403010) Fasting plasma glucose ( 28270201) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Offspring birth weight ( 31043758) Pulse pressure ( 27841878) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 30054458)
Interacting Genes		26 interacting genes: APP DNAJC19 DNLZ ERBB2 ERCC6 FGF1 HSP90B1 HSPBP1 LAMTOR5 LINC01554 LSM8 MATK MVD NELFB PTPN11 PTPRF SIRPA STUB1 SUMO2 SUMO4 SUPT6H TIMM44 TP53 XPO1 YKT6 YWHAG	3 interacting genes: BET1L HSPA9 USO1
Entrez ID		3313	10652
HPRD ID		02770	16205
Ensembl ID		ENSG00000113013	ENSG00000106636
Uniprot IDs		A0A384P5G6 P38646	A4D2J0 O15498
PDB IDs		3N8E 4KBO 6NHK 6P2U 6PMT	6J74 6J7F 6J7X
Enriched GO Terms of Interacting Partners?
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