HDGF and GPR37

Data Source:
BioGRID (two hybrid)

		HDGF	GPR37
Description		heparin binding growth factor	G protein-coupled receptor 37
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Collagen-containing Extracellular Matrix	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Nucleotide Binding Transcription Corepressor Binding Double-stranded DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity RNA Binding Growth Factor Activity Heparin Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Signal Transduction IRE1-mediated Unfolded Protein Response Cellular Response To Interleukin-7	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		XBP1(S) activates chaperone genes	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Refractive error ( 32231278)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: APP GPR37 JUN SMAD4 XBP1	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		3068	2861
HPRD ID		02079	03992
Ensembl ID		ENSG00000143321	ENSG00000170775
Uniprot IDs		A0A384NPW1 A8K8G0 B7Z958 P51858	O15354
PDB IDs		1RI0 2NLU
Enriched GO Terms of Interacting Partners?
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