GZMB and NEK9

Data Source:
BioGRID (affinity chromatography technology)

		GZMB	NEK9
Description		granzyme B	NIMA related kinase 9
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Centrosome Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways		NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		3002	91754
HPRD ID		00476	11386
Ensembl ID		ENSG00000100453	ENSG00000119638
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	Q6PKF2 Q8TD19
PDB IDs		1FQ3 1IAU	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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