GZMB and UBE4A

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		GZMB	UBE4A
Description		granzyme B	ubiquitination factor E4A
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway
Pathways		NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		3002	9354
HPRD ID		00476	06793
Ensembl ID		ENSG00000100453	ENSG00000110344
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	Q14139
PDB IDs		1FQ3 1IAU	1WGM
Enriched GO Terms of Interacting Partners?
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