GZMB and XRCC4

Data Source:
HPRD (in vivo)

		GZMB	XRCC4
Description		granzyme B	X-ray repair cross complementing 4
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GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency Protein Localization To Site Of Double-strand Break
Pathways		NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria	2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 PNKP PRKDC VIM
Entrez ID		3002	7518
HPRD ID		00476	15951
Ensembl ID		ENSG00000100453	ENSG00000152422
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763
PDB IDs		1FQ3 1IAU	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO
Enriched GO Terms of Interacting Partners?
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