TBK1 and SMCR8

Data Source:
BioGRID (enzymatic study)

		TBK1	SMCR8
Description		TANK binding kinase 1	SMCR8-C9orf72 complex subunit
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Activation Of Innate Immune Response Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Viral Process Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Neuron Death Positive Regulation Of Xenophagy	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways		IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Potential therapeutics for SARS
Drugs		Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793 27455348) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		44 interacting genes: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG CYLD HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 MAP1LC3B MAVS MBP MIB2 MTPAP NCK1 NEDD4 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 SQSTM1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TRIM27 TXLNG XIAP	4 interacting genes: ATG13 C9orf72 TBK1 ULK1
Entrez ID		29110	140775
HPRD ID		05322	18075
Ensembl ID		ENSG00000183735	ENSG00000176994
Uniprot IDs		Q9UHD2	Q8TEV9
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU	6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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