GPS1 and CUL4A

Data Source:
BioGRID (pull down)

		GPS1	CUL4A
Description		G protein pathway suppressor 1	cullin 4A
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Nucleoplasm SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Inactivation Of MAPK Activity Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair JNK Cascade Negative Regulation Of GTPase Activity Post-translational Protein Modification	G1/S Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Viral Process Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision Somatic Stem Cell Population Maintenance Ribosome Biogenesis DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Regulation Of Protein Metabolic Process Global Genome Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494 27863252) Red cell distribution width ( 32888494)
Interacting Genes		29 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 ELOB IP6K1 ITPK1 RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	24 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS5 DCAF6 DCUN1D4 DDB1 DDB2 ERCC8 GPS1 H1-2 H3C1 HOXA9 KPNB1 RBX1 RNF7 SALL2 SENP8 SKP2 TUBG1 UBC UBE2E3
Entrez ID		2873	8451
HPRD ID		15991	07218
Ensembl ID		ENSG00000169727	ENSG00000139842
Uniprot IDs		A0A096LP07 A0A096LPJ3 C9JFE4 Q13098	A0A0A0MR50 Q13619
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	2HYE 4A0K
Enriched GO Terms of Interacting Partners?
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