GPS1 and ITPK1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		GPS1	ITPK1
Description		G protein pathway suppressor 1	inositol-tetrakisphosphate 1-kinase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Cytoplasm Cytosol Apical Plasma Membrane
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Magnesium Ion Binding Inositol Tetrakisphosphate 6-kinase Activity Catalytic Activity ATP Binding Hydrolase Activity Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity
	Biological Process	Inactivation Of MAPK Activity Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair JNK Cascade Negative Regulation Of GTPase Activity Post-translational Protein Modification	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Inositol Phosphorylation Necroptotic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Body mass index ( 26426971) Chronic obstructive pulmonary disease ( 30804561) Endometriosis ( 23472165) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Migraine ( 27182965 27322543) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494 27863252) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL4A CUL5 DDB1 ELOB IP6K1 ITPK1 RBX1 SAP130 SENP8 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		2873	3705
HPRD ID		15991	03501
Ensembl ID		ENSG00000169727	ENSG00000100605
Uniprot IDs		A0A096LP07 A0A096LPJ3 C9JFE4 Q13098	A0A024R6H3 Q13572
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	2ODT 2Q7D 2QB5
Enriched GO Terms of Interacting Partners?
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