SCARA5 and EXOC8

Data Source:
BioGRID (two hybrid)

		SCARA5	EXOC8
Description		scavenger receptor class A member 5	exocyst complex component 8
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Exocyst Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Leading Edge Perinuclear Region Of Cytoplasm
	Molecular Function	Scavenger Receptor Activity Ferritin Receptor Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Cellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Cellular Protein Localization
Pathways		Scavenging by Class A Receptors	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Blood protein levels ( 29875488) Factor VIII levels ( 30586737) Lack of premeditation ( 30718321) Low vWF levels ( 26486471) Venous thromboembolism ( 31420334) vWF levels ( 30586737)	Hemoglobin concentration ( 27863252)
Interacting Genes		15 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 TMEM208 TSG101 WASHC3	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		286133	149371
HPRD ID		11356	09943
Ensembl ID		ENSG00000168079	ENSG00000116903
Uniprot IDs		Q6ZMJ2	Q8IYI6
PDB IDs		7C00
Enriched GO Terms of Interacting Partners?
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