SCARA5 and EHHADH

Data Source:
BioGRID (two hybrid)

		SCARA5	EHHADH
Description		scavenger receptor class A member 5	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Scavenger Receptor Activity Ferritin Receptor Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Enzyme Binding
	Biological Process	Cellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways		Scavenging by Class A Receptors	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Blood protein levels ( 29875488) Factor VIII levels ( 30586737) Lack of premeditation ( 30718321) Low vWF levels ( 26486471) Venous thromboembolism ( 31420334) vWF levels ( 30586737)	Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)
Interacting Genes		15 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 TMEM208 TSG101 WASHC3	100 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES EMP1 ERGIC1 FGF14 FUNDC1 GAS8 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD6 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17 ZRANB1
Entrez ID		286133	1962
HPRD ID		11356	06125
Ensembl ID		ENSG00000168079	ENSG00000113790
Uniprot IDs		Q6ZMJ2	Q08426
PDB IDs		7C00
Enriched GO Terms of Interacting Partners?
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