SCARA5 and P4HA3

Data Source:
BioGRID (two hybrid)

		SCARA5	P4HA3
Description		scavenger receptor class A member 5	prolyl 4-hydroxylase subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Scavenger Receptor Activity Ferritin Receptor Activity	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Cellular Iron Ion Homeostasis Endocytosis Cellular Response To Heat Iron Ion Transmembrane Transport Protein Homotrimerization	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Pathways		Scavenging by Class A Receptors	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325) Blood protein levels ( 29875488) Factor VIII levels ( 30586737) Lack of premeditation ( 30718321) Low vWF levels ( 26486471) Venous thromboembolism ( 31420334) vWF levels ( 30586737)	Hippocampal atrophy ( 25625606)
Interacting Genes		15 interacting genes: C1QL4 CMTM5 EHHADH EXOC8 FBXO7 KANK2 NTAQ1 P4HA3 PSMB1 RNF151 SLC35B4 SMARCD1 TMEM208 TSG101 WASHC3	50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A
Entrez ID		286133	283208
HPRD ID		11356	16413
Ensembl ID		ENSG00000168079	ENSG00000149380
Uniprot IDs		Q6ZMJ2	Q7Z4N8
PDB IDs		7C00
Enriched GO Terms of Interacting Partners?
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