GLUL and CRBN

Data Source:
BioGRID (enzymatic study, biochemical)

		GLUL	CRBN
Description		glutamate-ammonia ligase	cereblon
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Neurotransmitter Uptake Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Amino Acid Biosynthetic Process Regulation Of Endothelial Cell Migration Protein Phosphopantetheinylation Protein Palmitoylation Ribosome Biogenesis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism	Potential therapeutics for SARS
Drugs		L-Glutamine Glutamic acid	Lenalidomide Thalidomide Pomalidomide
Diseases		Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I	36 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		2752	51185
HPRD ID		00701	16750
Ensembl ID		ENSG00000135821	ENSG00000113851
Uniprot IDs		A8YXX4 P15104	Q96SW2
PDB IDs		2OJW 2QC8	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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