CRBN and HIC2

Data Source:
BioGRID (pull down)

		CRBN	HIC2
Description		cereblon	HIC ZBTB transcriptional repressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein C-terminus Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated
Pathways		Potential therapeutics for SARS
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Interacting Genes		36 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A
Entrez ID		51185	23119
HPRD ID		16750	07412
Ensembl ID		ENSG00000113851	ENSG00000169635
Uniprot IDs		Q96SW2	Q96JB3
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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