CRBN and CYP19A1

Data Source:
BioGRID (pull down)

		CRBN	CYP19A1
Description		cereblon	cytochrome P450 family 19 subfamily A member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Iron Ion Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process Female Gonad Development Sterol Metabolic Process Electron Transport Chain Response To Estradiol Positive Regulation Of Estradiol Secretion
Pathways		Potential therapeutics for SARS	Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Drugs		Lenalidomide Thalidomide Pomalidomide	Nicotine Aminoglutethimide Estrone Testolactone Exemestane Letrozole Anastrozole 2-Methoxyestradiol Naringenin Glyphosate MPI-674
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)	46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Aromatase excess syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Airway wall thickness ( 25517131) Breast cancer ( 31757997) Cerebrospinal fluid AB1-42 levels ( 20932310) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Estradiol levels ( 22675492 29325096) Estrone levels ( 29325096) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Follicle stimulating hormone levels ( 24049095) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 25429064 31562340 23456168 20189936) Hormone measurements ( 24049095) Lymphocyte percentage of white cells ( 32888494) Menarche (age at onset) ( 23599027) Neutrophil percentage of white cells ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 29403010) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378)
Interacting Genes		36 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	2 interacting genes: CRBN FANCG
Entrez ID		51185	1588
HPRD ID		16750	00488
Ensembl ID		ENSG00000113851	ENSG00000137869
Uniprot IDs		Q96SW2	A0A024R5S8 A8K6W3 P11511 Q05CU4 Q8IYG4 Q8TCA4
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 7BQU 7BQV	1TQA 3EQM 3S79 3S7S 4GL5 4GL7 4KQ8 5JKV 5JKW 5JL6 5JL7 5JL9
Enriched GO Terms of Interacting Partners?
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