RPS6KA6 and ZNF227

Data Source:
BioGRID (two hybrid)

		RPS6KA6	ZNF227
Description		ribosomal protein S6 kinase A6	zinc finger protein 227
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Nucleus
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	6 interacting genes: CDKN2A CEP70 CSNK1E GSK3B RPS6KA6 UMPS
Entrez ID		27330	7770
HPRD ID		02250	15752
Ensembl ID		ENSG00000072133	ENSG00000131115
Uniprot IDs		Q9UK32	B7Z6M2 Q658S5 Q86WZ6
PDB IDs		6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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