RPS6KA6 and CLEC3B

Data Source:
BioGRID (two hybrid)

		RPS6KA6	CLEC3B
Description		ribosomal protein S6 kinase A6	C-type lectin domain family 3 member B
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Granular Component Extracellular Region Extracellular Space Cytoplasm Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Ossification Platelet Degranulation Positive Regulation Of Plasminogen Activation Bone Mineralization Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Platelet degranulation
Drugs		Fostamatinib	Tenecteplase Lanoteplase Copper
Diseases
GWAS			Acne (severe) ( 24927181) Blood protein levels ( 30072576)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	12 interacting genes: ANXA7 APP CDKN1A GADD45A GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1
Entrez ID		27330	7123
HPRD ID		02250	01759
Ensembl ID		ENSG00000072133	ENSG00000163815
Uniprot IDs		Q9UK32	E9PHK0 P05452
PDB IDs		6G76 6G77 6G78	1HTN 1RJH 1TN3 3L9J
Enriched GO Terms of Interacting Partners?
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