RPS6KA6 and MICAL1

Data Source:
BioGRID (two hybrid)

		RPS6KA6	MICAL1
Description		ribosomal protein S6 kinase A6	microtubule associated monooxygenase, calponin and LIM domain containing 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Factors involved in megakaryocyte development and platelet production
Drugs		Fostamatinib
Diseases
GWAS			Depression in smokers ( 30219690) Height ( 28552196)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		27330	64780
HPRD ID		02250	06183
Ensembl ID		ENSG00000072133	ENSG00000135596
Uniprot IDs		Q9UK32	Q8TDZ2
PDB IDs		6G76 6G77 6G78	1WYL 2CO8 2DK9 5LE0 5LPN 6KU0
Enriched GO Terms of Interacting Partners?
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