RPS6KA6 and SPTBN4

Data Source:
BioGRID (two hybrid)

		RPS6KA6	SPTBN4
Description		ribosomal protein S6 kinase A6	spectrin beta, non-erythrocytic 4
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	MAPK Cascade Regulation Of Sodium Ion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs		Fostamatinib
Diseases
GWAS			Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	15 interacting genes: ANK3 ARC CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		27330	57731
HPRD ID		02250	09372
Ensembl ID		ENSG00000072133	ENSG00000160460
Uniprot IDs		Q9UK32	Q9H254
PDB IDs		6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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