PABPC1 and GSPT1

Data Source:
HPRD (in vitro, in vivo)

		PABPC1	GSPT1
Description		poly(A) binding protein cytoplasmic 1	G1 to S phase transition 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytosol Translation Release Factor Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translational Initiation Gene Silencing By RNA Regulation Of MRNA Stability Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Regulation Of Translational Termination Protein Methylation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		45 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LINC01554 MAPKAPK2 NDRG1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	12 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CRBN DDB1 ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP
Entrez ID		26986	2935
HPRD ID		05247	00753
Ensembl ID		ENSG00000070756	ENSG00000103342
Uniprot IDs		A0A024R9C1 P11940	B2RCT6 P15170 Q7KZX8
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS	3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT
Enriched GO Terms of Interacting Partners?
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