PABPC1 and EIF4G3

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo, in vitro)

		PABPC1	EIF4G3
Description		poly(A) binding protein cytoplasmic 1	eukaryotic translation initiation factor 4 gamma 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytosol Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Translation Factor Activity, RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translational Initiation Gene Silencing By RNA Regulation Of MRNA Stability Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		45 interacting genes: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LINC01554 MAPKAPK2 NDRG1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RACK1 RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	8 interacting genes: CAMK1 EIF4A1 EIF4E HSPB1 LIG4 MKNK1 PABPC1 VAV2
Entrez ID		26986	8672
HPRD ID		05247	06802
Ensembl ID		ENSG00000070756	ENSG00000075151
Uniprot IDs		A0A024R9C1 P11940	A0A0A0MSA7 O43432 Q59GJ0
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS	1HU3
Enriched GO Terms of Interacting Partners?
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