GSPT1 and GSPT2

Data Source:
HPRD (two hybrid, in vivo)

		GSPT1	GSPT2
Description		G1 to S phase transition 1	G1 to S phase transition 2
Image
GO Annotations	Cellular Component	Cytosol Translation Release Factor Complex	Cytosol Translation Release Factor Complex
	Molecular Function	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Regulation Of Translational Termination Protein Methylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Cell Cycle
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		12 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CRBN DDB1 ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP	4 interacting genes: APP ETF1 GSPT1 PABPC1
Entrez ID		2935	23708
HPRD ID		00753	02334
Ensembl ID		ENSG00000103342	ENSG00000189369
Uniprot IDs		B2RCT6 P15170 Q7KZX8	Q8IYD1
PDB IDs		3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT	3KUJ
Enriched GO Terms of Interacting Partners?
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