GSPT1 and HINFP

Data Source:
BioGRID (two hybrid)

		GSPT1	HINFP
Description		G1 to S phase transition 1	histone H4 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Translation Release Factor Complex	Nucleus Nucleoplasm Nucleolus Cajal Body
	Molecular Function	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Regulation Of Translational Termination Protein Methylation	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Protein Localization Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		12 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CRBN DDB1 ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP	29 interacting genes: ATN1 CDYL2 EFTUD2 ELP4 GSPT1 IHO1 JUND MBD2 MDC1 MIF4GD MKI67 MORF4L1 NDUFAB1 NIPBL NPDC1 POM121C PRRC2C RBM17 RBM26 RPUSD4 TLE3 TP53 TRA2B TRAF2 TRIM39 TRIM44 TTF2 U2AF1 ZNHIT1
Entrez ID		2935	25988
HPRD ID		00753	07387
Ensembl ID		ENSG00000103342	ENSG00000172273
Uniprot IDs		B2RCT6 P15170 Q7KZX8	A0A024R3F5 Q9BQA5
PDB IDs		3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT
Enriched GO Terms of Interacting Partners?
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