NKX2-5 and TBX5

Data Source:
HPRD (in vivo, in vitro)

		NKX2-5	TBX5
Description		NK2 homeobox 5	T-box transcription factor 5
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Septum Secundum Development Regulation Of Transcription By RNA Polymerase II Adult Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction	Cell Fate Specification Morphogenesis Of An Epithelium Bundle Of His Development Atrioventricular Valve Morphogenesis Endocardial Cushion Development Cardiac Left Ventricle Formation Ventricular Septum Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell-cell Signaling Pattern Specification Process Heart Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Forelimb Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Pericardium Development Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Atrial Septum Morphogenesis Cell Migration Involved In Coronary Vasculogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases		Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)	Holt-Oram syndrome
GWAS		Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 32439900 20062060) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)	Airflow obstruction ( 22837378) Atrial fibrillation ( 28416818 28416822 30061737 29892015) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21909110) Bone mineral density (total hip) ( 29883787) Diastolic blood pressure ( 28135244 19430479 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) FEV1 ( 30804560) Hypertension ( 30487518) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Mean arterial pressure ( 30487518) Obesity-related traits ( 23251661) P wave duration ( 28794112) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 32184442) Percent mammographic density ( 22532574) PR interval ( 30046033 32439900 20062060 25035420 23139255 21347284) Prostate cancer ( 23535732 25939597) QRS duration ( 27577874 30012220 21076409) Receptive language ability ( 32635940) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Visceral fat ( 22589738)
Interacting Genes		18 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10	7 interacting genes: BAIAP2 FBXO25 GATA4 KAT5 KDM6A NKX2-5 ZMYND10
Entrez ID		1482	6910
HPRD ID		02787	03372
Ensembl ID		ENSG00000183072	ENSG00000089225
Uniprot IDs		A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952	Q99593
PDB IDs		3RKQ 4S0H 6WC2 6WC5	2X6U 2X6V 4S0H 5BQD
Enriched GO Terms of Interacting Partners?
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