SIN3A and MXD1

Data Source:
HPRD (two hybrid, in vivo)

		SIN3A	MXD1
Description		SIN3 transcription regulator family member A	MAX dimerization protein 1
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GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Nucleolus Sin3 Complex Transcription Repressor Complex	Chromatin Nucleoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding Transcription Regulator Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Protein Deacetylation Aging Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Regulation Of Lipid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Axon Extension Positive Regulation Of Chromatin Silencing Cellular Protein Localization Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Cellular Response To Dopamine Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)	Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		98 interacting genes: ARID4A ARID4B BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NCOR2 NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16	18 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3
Entrez ID		25942	4084
HPRD ID		09690	02487
Ensembl ID		ENSG00000169375	ENSG00000059728
Uniprot IDs		Q96ST3	B7ZLI7 Q05195
PDB IDs		1PO4	1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?
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