SIN3A and CIAO2A

Data Source:
BioGRID (two hybrid)

		SIN3A	CIAO2A
Description		SIN3 transcription regulator family member A	cytosolic iron-sulfur assembly component 2A
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GO Annotations	Cellular Component	Histone Deacetylase Complex Kinetochore Chromatin Nucleus Nucleoplasm Nucleolus Sin3 Complex Transcription Repressor Complex	Nucleoplasm Cytosol CIA Complex
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Binding Protein-containing Complex Binding Transcription Regulator Inhibitor Activity	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Hematopoietic Progenitor Cell Differentiation DNA Replication Protein Deacetylation Aging Regulation Of Hormone Levels Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Regulation Of Lipid Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Axon Extension Positive Regulation Of Chromatin Silencing Cellular Protein Localization Negative Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Response To Methylglyoxal Cellular Response To Glucose Stimulus Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Histone H3-K27 Acetylation Cellular Response To Dopamine Negative Regulation Of Transcription Regulatory Region DNA Binding	Chromosome Segregation Iron-sulfur Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer Protein Maturation By [4Fe-4S] Cluster Transfer
Pathways		SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Height ( 20189936) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Sudden cardiac arrest ( 21658281) Type 2 diabetes ( 32499647)
Interacting Genes		98 interacting genes: ARID4A ARID4B BCL11A BCL6 BCL6B BHLHE40 BNIP2 BRMS1 BRMS1L CBFA2T2 CIAO2A COPS2 CTBP1 CTCF CUL4B CYTOR DACH1 DDB1 DDX20 DHX30 ETV6 FOXK2 H3-4 HBP1 HCFC1 HDAC1 HDAC2 HDAC7 HDAC9 HEY2 HTT IKZF1 IKZF4 ING1 IRF5 KLF10 KLF11 KLF13 KLF16 KLF9 LRCH4 MAD1L1 MBD2 MBD4 MECP2 MEN1 MNT MORF4L2 MXD1 MXD4 MXI1 MYB NCOR2 NDRG4 NFKB1 NFKB2 NR2E3 OGT PA2G4 PBX3 PHB PHF12 PML PRMT5 PTEN PTMA RBBP4 RBBP7 RBP1 RBPJ REL RELA RELB RLIM RUNX1T1 SAP18 SAP30 SETDB1 SFPQ SH3GLB1 SKI SMAD3 SMARCA4 SMARCC1 SMARCE1 SNW1 SPI1 STAT3 SUMO2 SYT1 TAL1 TFCP2 TGIF1 THAP11 TOPORS TP53 TRIM28 ZBTB16	25 interacting genes: AGTRAP APOA2 CIAO1 CMTM6 CREB3L1 DERL1 DGAT2L6 EBAG9 ERGIC3 FKBP7 GJA8 GSC2 KCNIP1 LIME1 MEST PLP2 PLPP6 PLPPR2 PRAF2 RHBDD2 SETD4 SIN3A TMED8 TNFRSF10D VAMP3
Entrez ID		25942	84191
HPRD ID		09690	08010
Ensembl ID		ENSG00000169375	ENSG00000166797
Uniprot IDs		Q96ST3	Q9H5X1
PDB IDs		1PO4	2M5H 3UX2 3UX3
Enriched GO Terms of Interacting Partners?
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