MXD1 and SIN3B

Data Source:
HPRD (in vivo, in vitro)

		MXD1	SIN3B
Description		MAX dimerization protein 1	SIN3 transcription regulator family member B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Mitochondrion Cytosol	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process
Pathways			NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		18 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	20 interacting genes: AURKA COPS2 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16
Entrez ID		4084	23309
HPRD ID		02487	09691
Ensembl ID		ENSG00000059728	ENSG00000127511
Uniprot IDs		B7ZLI7 Q05195	B7Z392 M0QYC5 O75182
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?
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