MKRN1 and DUSP23

Data Source:
BioGRID (two hybrid)

		MKRN1	DUSP23
Description		makorin ring finger protein 1	dual specificity phosphatase 23
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination	Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs			4-Nitrophenyl Phosphate
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) ( 33208821) Immature fraction of reticulocytes ( 32888494) Number of sexual partners ( 30643258)	Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		23 interacting genes: APC ASH2L BYSL CSNK1G1 DAXX DUSP23 EXOSC8 FADD FAM161A MAP1LC3B MTURN NAA10 OTUB2 RAD23A RAD23B SDCBP SLC13A1 UBASH3A UBE2D1 UBE2D3 UBE2D4 UBE2W YOD1	32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746
Entrez ID		23608	54935
HPRD ID		09673	07908
Ensembl ID		ENSG00000133606	ENSG00000158716
Uniprot IDs		Q9UHC7	A0A140VJI5 Q9BVJ7
PDB IDs			2IMG 4ERC
Enriched GO Terms of Interacting Partners?
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