SF3B3 and OSGEP

Data Source:
BioGRID (two hybrid)

		SF3B3	OSGEP
Description		splicing factor 3b subunit 3	O-sialoglycoprotein endopeptidase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2 SnRNP U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	EKC/KEOPS Complex Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Nucleic Acid Binding Protein Binding U2 SnRNA Binding Protein-containing Complex Binding	Protein Binding Metal Ion Binding N(6)-L-threonylcarbamoyladenine Synthase Activity
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of Protein Catabolic Process	TRNA Threonylcarbamoyladenosine Modification
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	tRNA modification in the nucleus and cytosol
Drugs		Quercetin
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061)	Food addiction ( 27106561)
Interacting Genes		104 interacting genes: APBB1 EFTUD2 EPS8 ERCC6 ERG HCK HGS HSPB1 KLF10 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MPP3 NAGK NOL12 OSGEP PHF5A PPIL1 PRPF40A RAD9A RBM6 RUFY2 SF3B1 SF3B6 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 U2AF2 WBP4 WWOX YWHAG ZNF579	25 interacting genes: CIAPIN1 CRIP2 EMCN GP1BA HPS6 LAGE3 LENG1 MUC1 NR3C1 NVL OPTC PDE4DIP PKP4 RBM48 REX1BD SF3B3 SHC1 SP110 SPRED1 TNS1 TP53RK WDR82 WIZ ZNF579 ZNF775
Entrez ID		23450	55644
HPRD ID		12027	10133
Ensembl ID		ENSG00000189091	ENSG00000092094
Uniprot IDs		A8K6V3 Q15393	Q9NPF4
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q	6GWJ
Enriched GO Terms of Interacting Partners?
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