MAPKBP1 and RBCK1

Data Source:
BioGRID (two hybrid)

		MAPKBP1	RBCK1
Description		mitogen-activated protein kinase binding protein 1	RANBP2-type and C3HC4-type zinc finger containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Mitotic Spindle Pole	Ubiquitin Ligase Complex Cytosol LUBAC Complex
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Interleukin-8 Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Bacterium	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Urinary albumin excretion ( 30220432) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Night sleep phenotypes ( 27126917)
Interacting Genes		62 interacting genes: ADAM12 ADAMTSL4 ALG13 APTX CTDSP1 CYSRT1 FOXN1 GLRX3 HOXA1 KEAP1 KPRP KRT31 KRT34 KRT35 KRT38 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 MAPK10 MAPK8 MAPK9 MDFI MEOX2 METTL15 MYOG NBPF19 NOTCH2NLA PLA2G10 PLSCR3 RBCK1 RGS20 SIAH1 SPRY2 SPRY3 TCF12 TCF4 TEKT5 TEX11 TRIM27 TRIM42 TRIP6 YPEL5 ZNF34	65 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MALT1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		23005	10616
HPRD ID		17465	16643
Ensembl ID		ENSG00000137802	ENSG00000125826
Uniprot IDs		O60336	A6PVJ6 A6PVK0 Q9BYM8
PDB IDs			2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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