RBCK1 and IREB2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		RBCK1	IREB2
Description		RANBP2-type and C3HC4-type zinc finger containing 1	iron responsive element binding protein 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Tricarboxylic Acid Cycle Citrate Metabolic Process Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Post-embryonic Development Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis Intestinal Absorption Iron Ion Homeostasis
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Iron uptake and transport
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 25241909 22080838 20173748) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 25056061 29483656)
Interacting Genes		65 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MALT1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	6 interacting genes: APP FBXL5 RBCK1 TERT USP53 YBX1
Entrez ID		10616	3658
HPRD ID		16643	08858
Ensembl ID		ENSG00000125826	ENSG00000136381
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	D3DW85 P48200
PDB IDs		2CRC 2LGY 4DBG	6VCD
Enriched GO Terms of Interacting Partners?
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