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RBCK1 and SOCS6
Data Source:
HPRD
(two hybrid, in vivo)
RBCK1
SOCS6
Description
RANBP2-type and C3HC4-type zinc finger containing 1
suppressor of cytokine signaling 6
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Cytosol
LUBAC Complex
Immunological Synapse
Cytoplasm
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
Protein Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Biological Process
Protein Polyubiquitination
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Necroptotic Process
Protein Linear Polyubiquitination
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Signal Transduction
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Intracellular Signal Transduction
Regulation Of Growth
Regulation Of Phosphatidylinositol 3-kinase Activity
Post-translational Protein Modification
Phosphatidylinositol Phosphorylation
Negative Regulation Of T Cell Activation
Pathways
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of KIT signaling
Neddylation
Negative regulation of FLT3
Drugs
Diseases
GWAS
Night sleep phenotypes (
27126917
)
Diverticular disease (
30177863
)
Night sleep phenotypes (
27126917
)
Systemic lupus erythematosus (
18204098
)
Type 2 diabetes (
29621232
)
Interacting Genes
65 interacting genes:
APP
ARNT2
BACH1
CREB5
CREBBP
ENKD1
GLYCTK
HGS
HOXA1
HOXC8
IL16
IREB2
KANK2
LNX1
MALT1
MAP3K1
MAPKBP1
MKRN2
NAA10
NDUFAF3
NEDD4
NR1I2
OTUB2
OTUD6A
PAN2
PCGF2
PRKCA
PRKN
PSMA1
PSMD4
RNF181
RNF31
SMURF1
SOCS6
SYCE1
TNFAIP3
TP53
TRAF1
TRIM21
TRIM25
TRIM65
TRIML1
TSSK3
TTC23
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2G1
UBE2K
UBE2L3
UBE2L6
UBE2N
UBE2S
UBE2U
UCHL5
UHRF2
USP15
USP2
USP21
USP32
USP49
USP7
ZNF414
39 interacting genes:
ACVR1
AMOT
APPL1
AR
BMPR1B
C1orf109
CLNK
CRK
DAB1
EFEMP1
EGFR
ELOB
ELOC
ERBB2
ERBB3
ERBB4
FRS3
GAB1
INSR
IRS2
IRS4
KDM1A
KIT
LNX1
MET
PIK3R1
PIK3R2
PIK3R3
RBCK1
RELA
SMURF2
TGFBR1
TUBA1A
TUBB4B
TXK
UBE2D2
UBE2I
WDR89
ZMIZ2
Entrez ID
10616
9306
HPRD ID
16643
05491
Ensembl ID
ENSG00000125826
ENSG00000170677
Uniprot IDs
A6PVJ6
A6PVK0
Q9BYM8
A0A024R379
O14544
PDB IDs
2CRC
2LGY
4DBG
2VIF
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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