RBCK1 and PAN2

Data Source:
BioGRID (two hybrid)

		RBCK1	PAN2
Description		RANBP2-type and C3HC4-type zinc finger containing 1	poly(A) specific ribonuclease subunit PAN2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	P-body Nucleus Cytosol PAN Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Protein Phosphopantetheinylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Deadenylation of mRNA
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Axial length ( 24144296) Height ( 25429064) Refractive error ( 32231278)
Interacting Genes		65 interacting genes: APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MALT1 MAP3K1 MAPKBP1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414	7 interacting genes: DYNLL1 PABPC1 PAN3 RBCK1 RNF144B TNRC6A TRIM35
Entrez ID		10616	9924
HPRD ID		16643	15640
Ensembl ID		ENSG00000125826	ENSG00000135473
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	Q504Q3
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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