RPIA and TXN2

Data Source:
BioGRID (two hybrid)

		RPIA	TXN2
Description		ribose 5-phosphate isomerase A	thioredoxin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intracellular Membrane-bounded Organelle	Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body
	Molecular Function	Ribose-5-phosphate Isomerase Activity Protein Binding Identical Protein Binding Monosaccharide Binding	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity Protein Disulfide Oxidoreductase Activity Peptide-methionine (R)-S-oxide Reductase Activity Protein-containing Complex Binding
	Biological Process	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Ribose Phosphate Metabolic Process	Sulfur Amino Acid Catabolic Process Response To Hypoxia Glycerol Ether Metabolic Process Response To Oxidative Stress Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Response To Drug Cell Redox Homeostasis Response To Axon Injury
Pathways		RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway	Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
Drugs		4-phospho-L-threonic acid
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		19 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1	79 interacting genes: ABI3 AGTRAP ALDOB ANKRD36B AP2B1 BCAS2 BHLHB9 C11orf49 CCDC197 CDCA4 CEP70 CGGBP1 CHMP1A CIB4 CRACR2B DCTD DDIT3 ETHE1 FAM9B FHL5 FMNL2 GOLGA6L9 GPRASP2 GTPBP2 GUCD1 HAUS1 HAUS8 KAZN KRT18 KRT27 KRT40 LCN2 MAGEA11 MAGEA4 MAGEB2 MAPRE2 MAPRE3 MDFI MEOX2 MIPOL1 MLH1 MRFAP1 MRFAP1L1 MTUS2 MYL9 NUTM1 ODAD1 PEX19 POMC PPCDC PPP1R16B PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SAT1 SCYL3 SHARPIN SPTA1 SSNA1 STN1 STUB1 SYCE1 TFIP11 THAP1 TIFA TMOD4 TRIM21 TRIP6 TTC32 UCHL5 UQCC2 VIM VPS52 ZBTB14 ZMYND12 ZSCAN32
Entrez ID		22934	25828
HPRD ID		01589	07161
Ensembl ID		ENSG00000153574	ENSG00000100348
Uniprot IDs		P49247	Q99757
PDB IDs			1UVZ 1W4V 1W89
Enriched GO Terms of Interacting Partners?
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