FH and LMNB2

Data Source:
BioGRID (two hybrid)

		FH	LMNB2
Description		fumarate hydratase	lamin B2
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome	Nuclear Inner Membrane Intermediate Filament Nuclear Membrane
	Molecular Function	Fumarate Hydratase Activity Protein Binding	Molecular_function Protein Binding Identical Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis	Biological_process
Pathways		Citric acid cycle (TCA cycle)
Drugs
Diseases		Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	30 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LMNA LMNB1 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3
Entrez ID		2271	84823
HPRD ID		00652	01037
Ensembl ID		ENSG00000091483	ENSG00000176619
Uniprot IDs		A0A0S2Z4C3 P07954	Q03252
PDB IDs		3E04 5D6B 5UPP 6EBT	2LLL 5BNW
Enriched GO Terms of Interacting Partners?
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