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FH and EXOSC5
Data Source:
BioGRID
(two hybrid)
FH
EXOSC5
Description
fumarate hydratase
exosome component 5
Image
GO Annotations
Cellular Component
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Tricarboxylic Acid Cycle Enzyme Complex
Extracellular Exosome
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Fumarate Hydratase Activity
Protein Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Tricarboxylic Acid Cycle
Fumarate Metabolic Process
Malate Metabolic Process
DNA Repair
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Cold-induced Thermogenesis
RRNA Processing
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
Citric acid cycle (TCA cycle)
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
Renal cell carcinoma
Multiple cutaneous and uterine leiomyomata
Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS
Daytime sleep phenotypes (
27126917
)
Major depressive disorder (
27479909
)
Metabolite levels (
23823483
)
Interacting Genes
17 interacting genes:
C11orf49
CCDC102B
CCDC57
CCNDBP1
DGCR6
EXOSC5
GRB2
H2AZ1
KLHL6
LMNB2
MDH2
PIM1
POLR1C
PRKDC
SAT1
TNPO2
TTC19
80 interacting genes:
ACOT11
ADAMTSL4
BIRC2
BORCS6
CALCOCO2
CCDC88B
CDK5RAP1
DAAM2
DDIT4L
DHRS2
DIS3
DMRTB1
DOCK8
EFHC2
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
FH
FHL3
GOLGA2
HBS1L
HOXC4
IKZF3
KCTD13
KIAA1217
KRT13
KRT27
KRT31
KRT34
KRT35
LCA5L
LIPG
LRMDA
LSM3
LSM5
LZTS2
MEOX2
MPHOSPH6
MTMR3
MTREX
MYLIP
NKAPD1
NMI
NUP210
PA2G4
PALS2
PEG10
PICK1
PIH1D2
PKM
POLR2L
PRDM6
PTEN
REL
SFPQ
SH3GLB1
SH3GLB2
SHISA6
SNW1
SPTA1
TEX11
TFIP11
TLE5
TNFAIP1
TRIB3
TRIM54
TRIM62
ZFP90
ZMAT1
ZNF420
ZNF558
ZNF620
ZNF655
ZNF792
Entrez ID
2271
56915
HPRD ID
00652
16222
Ensembl ID
ENSG00000091483
ENSG00000077348
Uniprot IDs
A0A0S2Z4C3
P07954
Q9NQT4
PDB IDs
3E04
5D6B
5UPP
6EBT
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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