FH and MDH2

Data Source:
HPRD (in vitro)

		FH	MDH2
Description		fumarate hydratase	malate dehydrogenase 2
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Fumarate Hydratase Activity Protein Binding	RNA Binding L-malate Dehydrogenase Activity Protein Self-association Malate Dehydrogenase (NADP+) Activity
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process Aerobic Respiration
Pathways		Citric acid cycle (TCA cycle)	Gluconeogenesis Citric acid cycle (TCA cycle)
Drugs			NADH Citric acid Xanthinol
Diseases		Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)	Coffee consumption ( 31959922)
Interacting Genes		17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	8 interacting genes: CRYAB CS FH GOT2 HSPB1 NDUFS1 PC WARS1
Entrez ID		2271	4191
HPRD ID		00652	01099
Ensembl ID		ENSG00000091483	ENSG00000146701
Uniprot IDs		A0A0S2Z4C3 P07954	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		3E04 5D6B 5UPP 6EBT	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
Enriched GO Terms of Interacting Partners?
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