LMNB2 and OVOL1

Data Source:
BioGRID (two hybrid)

		LMNB2	OVOL1
Description		lamin B2	ovo like transcriptional repressor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Intermediate Filament Nuclear Membrane	Nucleus
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Biological_process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Spermatogenesis Mesoderm Development Epidermal Cell Differentiation Skin Development Germline Cell Cycle Switching, Mitotic To Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle Phase Transition Negative Regulation Of Stem Cell Proliferation
Pathways
Drugs
Diseases
GWAS			Acne (severe) ( 24927181 30542056) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 23042114 22197932 26482879) Atopic march ( 26542096) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 29875488) Breast cancer ( 23535729) Chronic kidney disease ( 20383146) DNA methylation (variation) ( 23725790) Eczema ( 31361310) Estimated glomerular filtration rate ( 31451708) High density lipoprotein cholesterol levels ( 31928498) Medication use (diuretics) ( 31015401) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211) Systemic lupus erythematosus ( 26502338 28714469) Systolic blood pressure ( 31928498) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Urate levels ( 23263486) Waist circumference ( 31928498)
Interacting Genes		30 interacting genes: AMOT AMOTL2 CA8 CCDC120 CCDC88B CDC37 EFHC2 FH GOLGA2 LMNA LMNB1 LZTS1 MFAP1 MID2 OVOL1 PIBF1 POU6F2 PPP1R13B PRKCD SVIL TFIP11 THAP1 TMPO TP53BP2 TRIM27 TSGA10IP USP2 WASHC3 ZC2HC1C ZFHX3	3 interacting genes: FAM90A1 LMNB2 MAFF
Entrez ID		84823	5017
HPRD ID		01037	09080
Ensembl ID		ENSG00000176619	ENSG00000172818
Uniprot IDs		Q03252	G3V1B0 O14753
PDB IDs		2LLL 5BNW
Enriched GO Terms of Interacting Partners?
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