EXOSC5 and ACOT11

Data Source:
BioGRID (two hybrid)

		EXOSC5	ACOT11
Description		exosome component 5	acyl-CoA thioesterase 11
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Mitochondrial Matrix Cytosol Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Lipid Binding Palmitoyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Response To Temperature Stimulus Response To Cold Intracellular Signal Transduction Negative Regulation Of Cold-induced Thermogenesis
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS			Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Epigenetic age acceleration in alcohol use disorder ( 31466081) Food allergy ( 25710614) Height ( 28552196) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Survival in pancreatic cancer ( 28470677)
Interacting Genes		80 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HBS1L HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	9 interacting genes: C2CD6 CABP5 EXOSC5 GEMIN6 HDAC7 HGS MAGEB4 MKRN3 SUOX
Entrez ID		56915	26027
HPRD ID		16222	07075
Ensembl ID		ENSG00000077348	ENSG00000162390
Uniprot IDs		Q9NQT4	Q8WXI4
PDB IDs		2NN6 6D6Q 6D6R 6H25	3FO5 6VVQ
Enriched GO Terms of Interacting Partners?
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