EXOSC5 and MTMR3

Data Source:
BioGRID (two hybrid)

		EXOSC5	MTMR3
Description		exosome component 5	myotubularin related protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin	Cytoplasm Cytosol Membrane Extrinsic Component Of Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding	Phosphatidylinositol-3-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Autophagy Macroautophagy Peptidyl-tyrosine Dephosphorylation Cellular Response To Glucose Starvation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS			Cerebrospinal P-tau181p levels ( 28247064) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 22197929) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Lung cancer ( 21725308) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Nephropathy ( 21399633) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Tonsillectomy ( 27941131 27182965 28928442) Type 2 diabetes ( 30297969 29632382)
Interacting Genes		80 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HBS1L HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792	4 interacting genes: EXOSC5 FGFR2 HIVEP1 LONRF1
Entrez ID		56915	8897
HPRD ID		16222	09151
Ensembl ID		ENSG00000077348	ENSG00000100330
Uniprot IDs		Q9NQT4	A0A024R1I2 Q13615
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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