FANCG and UIMC1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		FANCG	UIMC1
Description		FA complementation group G	ubiquitin interaction motif containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Plasma Membrane Fanconi Anaemia Nuclear Complex	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex
	Molecular Function	Damaged DNA Binding Protein Binding	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Ovarian Follicle Development DNA Repair Cellular Response To DNA Damage Stimulus Mitochondrion Organization Spermatid Development Response To Radiation Interstrand Cross-link Repair	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways		Fanconi Anemia Pathway	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Fanconi anemia
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494)	Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		44 interacting genes: BRCA2 BRCC3 CAPN1 CBY2 CDK1 COG6 CTBP1 CYP19A1 CYP2E1 DOK5 ERCC4 FANCA FANCC FANCE FANCF FTSJ3 GABPB1 GATA1 GOLGA2 HES1 HGS IHO1 IKZF3 KRT13 KRT19 LNX2 MEOX2 NECAB2 NLGN3 PSMB1 RINT1 RTN2 SAMD3 SSX2IP TADA2A TCEANC TFIP11 TLE5 TPRX1 UIMC1 USHBP1 XRCC3 ZBED1 ZBTB1	22 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3
Entrez ID		2189	51720
HPRD ID		04262	11482
Ensembl ID		ENSG00000221829	ENSG00000087206
Uniprot IDs		O15287 Q53XM5	A0A024R7R0 Q96RL1
PDB IDs			2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?
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