UIMC1 and ATP8A2

Data Source:
BioGRID (enzymatic study)

		UIMC1	ATP8A2
Description		ubiquitin interaction motif containing 1	ATPase phospholipid transporting 8A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex	Photoreceptor Outer Segment Nucleoplasm Endosome Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Magnesium Ion Binding Protein Binding ATP Binding ATPase Activity Phosphatidylethanolamine Flippase Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylserine Flippase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Involuntary Skeletal Muscle Contraction Axonogenesis Aging Negative Regulation Of Cell Population Proliferation Retina Layer Formation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Positive Regulation Of Multicellular Organism Growth Inner Ear Morphogenesis Eating Behavior Skin Development Phospholipid Translocation Neuron Development Neuromuscular Process Controlling Posture Detection Of Light Stimulus Involved In Visual Perception Neurofilament Cytoskeleton Organization Positive Regulation Of Phospholipid Translocation Aminophospholipid Translocation
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Common carotid intima-media thickness ( 29206233) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Eating disorders ( 23568457) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3	1 interacting genes: UIMC1
Entrez ID		51720	51761
HPRD ID		11482	05795
Ensembl ID		ENSG00000087206	ENSG00000132932
Uniprot IDs		A0A024R7R0 Q96RL1	B7Z880 Q6ZU25 Q9NTI2
PDB IDs		2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?
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