UIMC1 and BRCC3

Data Source:
BioGRID (pull down, affinity chromatography technology)

		UIMC1	BRCC3
Description		ubiquitin interaction motif containing 1	BRCA1/BRCA2-containing complex subunit 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body BRCA1-A Complex	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	DNA Binding Protein Binding Histone Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Venous thromboembolism ( 31676865)
Interacting Genes		22 interacting genes: ABRAXAS1 ATP8A2 BRCC3 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 UBB UBC USP13 WBP2 ZMYM3	11 interacting genes: ANKRD11 BRCA1 FANCG IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		51720	79184
HPRD ID		11482	06465
Ensembl ID		ENSG00000087206	ENSG00000185515
Uniprot IDs		A0A024R7R0 Q96RL1	P46736
PDB IDs		2MKF 2MKG 2N9E 2RR9	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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