FANCD2 and USP1

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo)

		FANCD2	USP1
Description		FA complementation group D2	ubiquitin specific peptidase 1
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding DNA Polymerase Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity
	Biological Process	Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases		Fanconi anemia
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1	15 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K
Entrez ID		2177	7398
HPRD ID		01968	04593
Ensembl ID		ENSG00000144554	ENSG00000162607
Uniprot IDs		Q9BXW9	O94782
PDB IDs		6VAA 6VAD 6VAE 6VAF	6DO5
Enriched GO Terms of Interacting Partners?
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