FANCD2 and UHRF2

Data Source:
BioGRID (affinity chromatography technology, imaging technique, pull down)

		FANCD2	UHRF2
Description		FA complementation group D2	ubiquitin like with PHD and ring finger domains 2
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body	Heterochromatin Nucleus Nucleoplasm Pericentric Heterochromatin
	Molecular Function	Protein Binding DNA Polymerase Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Histone Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway	Cell Cycle Maintenance Of DNA Methylation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	SUMOylation of transcription cofactors
Drugs
Diseases		Fanconi anemia
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)
Interacting Genes		28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1	38 interacting genes: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 YY1 ZNF410 ZNF618
Entrez ID		2177	115426
HPRD ID		01968	18257
Ensembl ID		ENSG00000144554	ENSG00000147854
Uniprot IDs		Q9BXW9	Q96PU4
PDB IDs		6VAA 6VAD 6VAE 6VAF	1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO
Enriched GO Terms of Interacting Partners?
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