USP1 and FANCI

Data Source:
BioGRID (enzymatic study, enzymatic study, pull down)

		USP1	FANCI
Description		ubiquitin specific peptidase 1	FA complementation group I
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity	DNA Binding Protein Binding DNA Polymerase Binding
	Biological Process	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Fanconi anemia
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Height ( 25282103) Menopause (age at onset) ( 26414677) Red cell distribution width ( 32888494) Serum immune biomarker levels ( 32066700)
Interacting Genes		15 interacting genes: DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 KPNA1 NMRAL1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K	13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48
Entrez ID		7398	55215
HPRD ID		04593	13339
Ensembl ID		ENSG00000162607	ENSG00000140525
Uniprot IDs		O94782	B3KNW8 Q9NVI1
PDB IDs		6DO5	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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