C4orf46 and HUS1

Data Source:
BioGRID (two hybrid)

		C4orf46	HUS1
Description		chromosome 4 open reading frame 46	HUS1 checkpoint clamp component
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break
	Molecular Function	Protein Binding	Protein Binding
	Biological Process		DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Acylcarnitine levels ( 26068415)	Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		10 interacting genes: APP BLOC1S6 CDR2 CDR2L HSF2BP HUS1 KXD1 PICK1 SRPK2 TFPT	28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ
Entrez ID		201725	3364
HPRD ID		17319	04787
Ensembl ID		ENSG00000205208	ENSG00000136273
Uniprot IDs		Q504U0	A4D2F2 O60921
PDB IDs			3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
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