EIF4A2 and PFDN1

Data Source:
BioGRID (two hybrid)

		EIF4A2	PFDN1
Description		eukaryotic translation initiation factor 4A2	prefoldin subunit 1
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Cytoplasm Prefoldin Complex
	Molecular Function	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS			Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		1974	5201
HPRD ID		03062	05357
Ensembl ID		ENSG00000156976	ENSG00000113068
Uniprot IDs		Q14240	O60925
PDB IDs		3BOR	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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