EIF4A2 and IPO11

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		EIF4A2	IPO11
Description		eukaryotic translation initiation factor 4A2	importin 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nuclear Envelope Nucleoplasm Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity	Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Alcohol and nicotine co-dependence ( 23216389) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) General risk tolerance (MTAG) ( 30643258) Interstitial lung abnormalities ( 31339356) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Subpleural-predominant interstitial lung abnormalities ( 31339356)
Interacting Genes		23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	12 interacting genes: C1orf94 EIF4A2 KEAP1 KRT76 NXF1 PLCD4 RAN RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3
Entrez ID		1974	51194
HPRD ID		03062	10003
Ensembl ID		ENSG00000156976	ENSG00000086200
Uniprot IDs		Q14240	Q9UI26
PDB IDs		3BOR
Enriched GO Terms of Interacting Partners?
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