PFDN1 and RPS28

Data Source:
BioGRID (two hybrid)

		PFDN1	RPS28
Description		prefoldin subunit 1	ribosomal protein S28
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Nucleoplasm Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Polysomal Ribosome Extracellular Exosome Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	12 interacting genes: CCNDBP1 CTBP2 EEF1G HSF2BP KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP2-4 KRTAP4-12 NOTCH2NLA PFDN1
Entrez ID		5201	6234
HPRD ID		05357	04731
Ensembl ID		ENSG00000113068	ENSG00000233927
Uniprot IDs		O60925	B2R4R9 P62857
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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